Immunolocalization of the calcium-sensing receptor in developing human kidney
نویسندگان
چکیده
منابع مشابه
Immunohistochemical Localization of Calcium-Sensing Receptor in the Rat Kidney
Calcium-sensing receptor (CaSR) plays a pivotal role in calcium homeostasis. Although CaSR mRNA has been detected in the kidney, its precise location is not known. We generated a polyclonal antibody against the extracellular domain of human kidney CaSR and studied its localization by immunohistochemical methods. By Western blotting, our anti-CaSR antibody recognized bands with molecular weights...
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The discovery of the calcium-sensing receptor (CaR), a G protein-coupled receptor, has led to the elucidation of the pivotal roles of the CaR in systemic calcium homeostasis. The receptor is situated on the chief cells of the parathyroid glands, where it senses the extracellular Ca2+ concentration and in turn alters the rate of secretion of parathyroid hormone (PTH). The intracellular signal pa...
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The calcium-sensing receptor (CaSR) was cloned over 20 years ago and functionally demonstrated to regulate circulating levels of parathyroid hormone by maintaining physiological serum ionized calcium concentration ([Ca(2+)]). The receptor is highly expressed in the kidney; however, intrarenal and intraspecies distribution remains controversial. Recently, additional functions of the CaSR recepto...
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ژورنال
عنوان ژورنال: Pediatric Research
سال: 2013
ISSN: 0031-3998,1530-0447
DOI: 10.1038/pr.2013.72